AN ADAPTIVE TWO-ARM CLINICAL TRIAL USING EARLY ENDPOINTS TO INFORM DECISION MAKING: DESIGN FOR A STUDY OF SUB-ACROMIAL SPACERS FOR REPAIR OF ROTATOR CUFF TENDON TEARS

Abstract Background There is widespread concern across the clinical and research communities that clinical trials, powered for patient-reported outcomes, testing new surgical procedures are often expensive and time-consuming, particularly when the new intervention is shown to be no better than the standard.Conventional (non-adaptive) randomised con

The Catholic Youth Association (Pol.KSM) operates within 41 dioceses of the Roman Catholic Church in Poland and, according HR Transmitter Board to data from 2019, has approx.20,000 members in almost 1,000 parish units and community circles.Numerous initiatives undertaken by KSM include, among others, activities aimed at protecting creation.This stu

Abstract We present analytical formulas for the Sommerfeld corrections to the annihilation of massive colored particles into quarks and gluons CHEESECLOTH through the strong interaction.These corrections are essential to accurately compute the dark matter relic density for coannihilation with colored partners.Our formulas allow us to compute the So

This paper investigates a patrol problem based on air-ground cooperation between multiple UAVs and police vehicles.Facing the uncertainty of patrol environment and patrol resources, the model guarantees the deterrence and emergency response capability of the patrol mission by optimizing the allocation strategy of patrol points and patrol routes.Rel